DeMille is a pioneering physicist who has developed novel methods of precision measurement to probe for the existence of new particles and forces that exist outside the standard model of particle physics, the theoretical framework that explains the most basic known building blocks of the universe and the forces that govern it.  

The majority of DeMille’s research in experimental physics is focused on solving the mystery of matter to anti-matter asymmetry. DeMille seeks to explain the discrepancy between the amount of matter and anti-matter in the observable universe by creating techniques for manipulating quantum states of molecules, and using these methods in the search for evidence of new particles and forces with properties that would explain the matter-antimatter asymmetry. DeMille’s research in molecular systems and precision measurement has exciting interdisciplinary applications to quantum sensing and quantum computation as well. 

DeMille joined Johns Hopkins University as a Bloomberg Distinguished Professor in 2025 from the University of Chicago. He is part of the Hub for Imaging and Quantum Technologies Cluster.