Christopher Chute is a physician-scientist and biomedical informatician focused on how clinical information can be computationally represented. He is widely known for standardizing biomedical terminologies and health information technology standards. Chute works on developing ways to manage data as a first-rank resource to enable evidence-based clinical practice and translational research.

Chute has a deep interest in semantic consistency, harmonized information models, and ontology. Chute works to ensure that clinical data is represented in a comparable and consistent manner in order to improve medical practice. He notably pioneered the use of electronic medical records in genetic research. As the Chief Research Information Officer of Johns Hopkins Medicine, his current research focuses on translating basic science information to clinical practice, as well as on how diseases are classified.

Chute joined Johns Hopkins University as a Bloomberg Distinguished Professor in 2015 from the Mayo Clinic.